Effectiveness of proton pump inhibitor in unexplained chronic cough

Effectiveness of proton pump inhibitor in unexplained chronic cough

BACKGROUND Current guidelines recommend that patients with unexplained chronic cough undergo empirical proton pump inhibitor (PPI) treatment, but scientific evidence for this treatment is lacking. We investigated the effectiveness and appropriate dose of PPI therapy in chronic cough. METHODS We included 27 patients with unexplained chronic cough after excluding subjects with positive response...

Proton pump inhibitor-responsive chronic cough without acid reflux: a case report

BACKGROUND Because 24-h esophageal pH monitoring is quite invasive, the diagnosis of gastroesophageal reflux disease (GERD)-associated cough has usually been made based merely on the clinical efficacy of treatment with proton pump inhibitor (PPI). CASE PRESENTATION We recently encountered two patients with PPI-responsive chronic non-productive cough for whom switching from bronchodilators and...

Author ' s response to reviews Proton pump inhibitor - responsive chronic cough without acid reflux

Gastrobronchial Fistula Presenting with Unexplained Chronic Cough

A gastrobronchial fistula (GBF) is a rare and life-threatening disease. The prognosis in patients with GBF is related to early diagnosis and urgent surgical intervention. We report a rare case of fistulous communication between the stomach and the residual pleural space, presenting with a 1-month history of coughing. The patient was initially misdiagnosed as having bronchitis. When patients pre...

Proton - pump inhibitor - responsive esophageal

Recent findings Several prospective series have reported consistent rates of PPI-REE (30–40%) in adults with suspected EoE. At baseline, PPI-REE and EoE have been shown to be indistinguishable upon clinical, endoscopic, and molecular characteristics [eotaxin-3, interleukin (IL-5), and IL-13 expression]. PPI therapy partially restores esophageal mucosal integrity in PPI-REE, but not in EoE. Anti...